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Image Search Results
Journal: bioRxiv
Article Title: Integrated Single-Cell and Spatial Transcriptomic Analysis Reveals an Aging-Associated Fibroblast Subtype Linked to Tumor Progression in Human Skin
doi: 10.1101/2025.07.09.663827
Figure Lengend Snippet: (A–C) UMAP plots of Visium spatial spots from SCC samples. (A) Spots colored by sample origin. (B) Spots labeled by spatial zones (core, edge, surrounding). (C) Grouped zones highlight transcriptomic patterns at tumor boundaries. (D) Heatmap showing spatial proximity among tumor zones. Higher intensity indicates closer spatial interaction, illustrating SCC microenvironment organization. (E) Ligand–receptor analysis identifies fibroblast-derived SFRP2 interacting with LRP5/6, suggesting Wnt signaling activation. (F) Spatial maps of SFRP2⁺ fibroblasts and Wnt signaling scores in SCC. Enrichment in tumor cores and interfaces points to fibroblast-driven modulation of the tumor niche.
Article Snippet:
Techniques: Labeling, Derivative Assay, Activation Assay